Small Molecules - Apoptosis, Cellular Oxidative Stress,

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Product Name: Ebselen
Catalog #: SIH-204-50MG
Size: 50mg
Type: Inhibitor
Description: Glutathione peroxidase mimic
Research Area: Apoptosis
CAS Number: 60940-34-3
Formula: C13H9NOSe
Molecular weight: 274.18
Source/Host: Synthetic
Purity: >99%
Solubility: Soluble in DMSO and 100% ethanol
Appearance: Off-white solid
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C
Safety Phrases: Classification: Harmful: May be harmful if inhaled, swallowed or absorbed through skin.

Safety Phrases: S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Risk Phrases: 23/25-33-50/53

Hazard Phrases: H301-H331-H373-H410

Precautionary Phrases: P261-P273-P301 + P310-P311-P501
Datasheet: SIH 204 Ebselen Apoptosis Inhibitor
Price: $109.00 USD Add to Cart Bulk Quote

Structure of Ebselen

Research Background: Ebselen or 2-phenyl-1, 2-benzisoselenazol-3(2H)-one (also called PZ 51 or DR3305), is a mimic of glutathione peroxidase and can also react with peroxynitrite (1). It is being investigated as a possible treatment for reperfusion injury and stroke (2, 3), as well as tinnitus (4). Ebselen is a potent scavenger of hydrogen peroxide as well as hydroperoxides including membrane bound phospholipid and cholesterylester hydroperoxides.
References: 1. Schewe T. (1995) Gen Pharmacol. 26(6): 1153-1169.
2. Parnham M, Seis H. (2000) Expert Opin Investig Drugs. 9(3): 607-619.
3. Yamaguchi T., et al. (1998) Stroke. 29(1): 12-17.
4. Kil J., Pierce C., Tran H., Gu R., Lynch E.D. (2007) Hearing Research. 226(1-2): 44-51.

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