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| Product Name | Mitomycin C |
| Description |
DNA synthesis inhibitor |
| Purity | >99% (TLC); NMR (Conforms) |
| CAS No. | 50-07-7 |
| Molecular Formula | C15H18N4O5 |
| Molecular Weight | 334.33 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (15mg/mL); or water (1mg/mL, warm) |
| Source | Synthetic |
| Appearance | Dark Purple Crystalline Solid |
| SMILES | CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N |
| InChI | InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H |
| InChIKey | NWIBSHFKIJFRCO-WUDYKRTCSA-N |
| Safety Phrases |
Classification: Very toxic. May be fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible) Risk Phrases: R26/27/28 - Very Toxic by inhalation, in contact with skin and if swallowed R46 - May cause heritable genetic damage R61 - May cause harm to the unborn child R62 - Possible risk of impaired fertility Hazard Phrases: H302-H351 Precautionary Phrases: P281 |
| Cite This Product | Mitomycin C (StressMarq Biosciences, Canada, Cat # SIH-246) |
Biological Description
| Alternative Names | [(1aS,8S,8aR,8bS)-6-Amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate, Ametycine |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 5746 |
| Scientific Background | The mitomycins are a family of aziridine containing natural products. Mitomycin C is a chemotherapeutic agent because of its mechanism of potent DNA crosslinker, reductive activation followed by two N-alklyations. Both alkylations are sequence specific for a guanine nucleoside in the sequence 5'-CpG-3' (1). |
| References | 1. Tomasz M. (1995). Chem and Biol. 2(9): 575-579. |
Product Images
Chemical structure of Mitomycin C (SIH-246), a DNA crosslinking and damaging agent. CAS #: 50-07-7. Molecular Formula: C15H18N4O5. Molecular Weight: 334.33 g/mol.
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Based on validation through cited publications.