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| Product Name | Troglitazone |
| Description |
PPARgamma agonist |
| Purity | >98% |
| CAS No. | 97322-87-7 |
| Molecular Formula | C24H27NO5S |
| Molecular Weight | 441.54 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Agonist |
| Solubility | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | CC1=C(C2=C(CCC(O2)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C(=C1O)C)C |
| InChI | InChI=1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H, |
| InChIKey | GXPHKUHSUJUWKP-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed R40 - Limited evidence of a carcinogenic effect |
| Cite This Product | Troglitazone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-260) |
Biological Description
| Alternative Names | 5-{4-[(6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione, Rezulin |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 5591 |
| Scientific Background | Troglitazone, a member of the thaizolidinediones, is an anti-diabetic and anti-inflammatory drug. It works by activating peroxisome proliferator-activated receptors (PPARs) (1). It is a ligand to both PPARalpha and gamma. It also contains an alpha-tocopheroyl moiety, potentially giving it vitamin E like activity (which helps in inflammation) (2). |
| References |
1. Lambe K.G. and Tugwood J.D. (1996) Eur J Biochem. 239(1): 1-7. 2. Aljada A., et al. (2001) J Clin Endocrinol Metab. 86(7): 3250-3256. |
Product Images
Chemical structure of Troglitazone (SIH-260), a PPARgamma agonist. CAS #: 97322-87-7. Molecular Formula: C24H27NO5S. Molecular Weight: 441.54 g/mol.
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