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| Product Name | b-AP15 (NSC-687852) |
| Description |
DUB inhibitor |
| Purity | >98% |
| CAS No. | 1009817-63-3 |
| Molecular Formula | C22H17N3O6 |
| Molecular Weight | 419.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 35 mg/ml DMSO |
| Source | Synthetic |
| Appearance | Pale Yellow Solid |
| SMILES | C=CC(=O)N1C/C(=CC2=CC=C(C=C2)[N+](=O)[O-])/C(=O)/C(=C/C3=CC=C(C=C3)[N+](=O)[O-])/C1 |
| InChI | InChI=1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22(27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+,18-12+ |
| InChIKey | GFARQYQBWJLZMW-JYFOCSDGSA-N |
| Safety Phrases |
Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | b-AP15 (NSC-687852) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-339) |
Biological Description
| Alternative Names | (3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)-4-piperidinone |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 5351435 |
| Scientific Background | Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. b-AP15 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo. |
| References | 1. D’Arcy P., et al. (2011) Nature Medicine 17: 1636. |
Product Images
Chemical structure of b-AP15 (NSC-687852) (SIH-339), a DUB inhibitor. CAS #: 1009817-63-3. Molecular Formula: C22H17N3O6. Molecular Weight: 419.4 g/mol.
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