SP600125

Jnk inhibitor

Catalog No. SIH-381

5 out of 5 based on 1 customer rating
CAS No. 129-56-6
Molecular Formula C14H8N2O
SKU: SIH-381 Categories: ,

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SIH-381_SP600125_Chemical_Structure.png
Product Name SP600125
Description

Jnk inhibitor

Purity >98%
CAS No. 129-56-6
Molecular Formula C14H8N2O
Molecular Weight 220.2
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO or methanol
Source Synthetic
Appearance Yellow to brown solid
SMILES C1=CC=C4C3=C1C(=O)C2=CC=CC=C2C3=N[NH]4
InChI InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
InChIKey ACPOUJIDANTYHO-UHFFFAOYSA-N
Safety Phrases Classification: D2B - Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H315 - Causes skin irritation.
H319 - Causes serious eye irritation.
H335 - May cause respiratory irritation
Precautionary Phrases:
P261 - Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 - Wash skin thoroughly after handling.
P271 - Use only outdoors or in a well-ventilated area.
P280 - Wear protective gloves/ eye protection/ face protection.
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 – Call a POISON CENTER or doctor/ physician if you feel unwell.
P321 - Specific treatment (see supplemental first aid instructions on this label).
P332 + P313 - If skin irritation occurs: Get medical advice/ attention.
P337 + P313 - If eye irritation persists: Get medical advice/ attention.
P362 - Take off contaminated clothing and wash before reuse.
P403 + P233 - Store in a well - ventilated place. Keep container tightly closed.
P405 - Store locked up.
P501 - Dispose of contents/ container to an approved waste disposal plant.
Cite This Product SP600125 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-381)

Biological Description

Alternative Names Anthra(1,9-cd)pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone
Research Areas Apoptosis, Cancer, Cell Signaling
PubChem ID 8515
Scientific Background Selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 > 10 µM). Active in vivo. Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis.
References 1. Bennett B.L., et al. (2001) Proc. Natl. Acad. Sci. U.S.A. 98(24): 13681-6.
2. Schnabl B., et al. (2001) Hepatology. 34(5): 953-63.
3. Bain J., et al. (2003) Biochem. J. 371(Pt 1): 199-204.
4. Wang Y., et al. (2007) Life Sci. 80(22): 2067-75.

Product Images

<p>Chemical structure of SP600125 (SIH-381), a Jnk inhibitor. CAS #: 129-56-6. Molecular Formula: C14H8N2O. Molecular Weight: 220.2 g/mol.</p>

Chemical structure of SP600125 (SIH-381), a Jnk inhibitor. CAS #: 129-56-6. Molecular Formula: C14H8N2O. Molecular Weight: 220.2 g/mol.

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