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| Product Name | A-803467 |
| Description |
NaV1.8 blocker |
| Purity | >98% |
| CAS No. | 944261-79-4 |
| Molecular Formula | C19H16ClNO4 |
| Molecular Weight | 357.79 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| Source | Synthetic |
| Appearance | Beige Solid |
| SMILES | COC1=CC(=CC(=C1)NC(=O)C2=CC=C(O2)C3=CC=C(C=C3)Cl)OC |
| InChI | InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22) |
| InChIKey | VHKBTPQDHDSBSP-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302 |
| Cite This Product | A-803467 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-304) |
Biological Description
| Alternative Names | 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide |
| Research Areas | Ion Channels, Neuroscience, Sodium Channels |
| PubChem ID | 16038374 |
| Scientific Background | A selective blocker of Nav1.8 channels. A-803467 potently reduced thermal hyperalgesia in inflammatory models of pain and mechanical allodynia in neuropathic models of pain, but was relatively ineffective in a skin-incision model of postoperative pain, a chemotherapy induced pain, and in visceral pain (1). |
| References | 1. Rush A.M., Cummins T.R. (2007) Mol Interv. 7(4): 192-195. |
Product Images
Chemical structure of A-803467 (SIH-304), a NaV1.8 blocker. CAS #: 944261-79-4. Molecular Formula: C19H16ClNO4. Molecular Weight: 357.79 g/mol.
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