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| Product Name | Andrographolide |
| Description |
Apoptosis Inducer |
| Purity | >98% |
| CAS No. | 5508-58-7 |
| Molecular Formula | C20H30O5 |
| Molecular Weight | 350.45 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | DMSO |
| Source | Synthetic |
| Appearance | Off-white Solid |
| SMILES | OC3COC(=O)C3=CC[C@@H]1C(=C)CC[C@@H]2C(C)(CO)[C@H](O)CC[C@@]12C |
| InChI | InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6 |
| InChIKey | BOJKULTULYSRAS-OTESTREVSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Andrographolide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-220) |
Biological Description
| Alternative Names | (3E)-4-Hydroxy-3-{2-[(1R,4aS,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydro-1-naphthalenyl]ethylidene}dihydro-2(3H)-furanone |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 5318517 |
| Scientific Background | Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata. Is has been shown to be effective against certain cancers, and is an effective purgative (1). It blocks T-cell proliferation to allogenic stimuli and the chemotactic migration of macrophages induced by complement (2, 3). |
| References |
1. Chakravarti R.N., Chakravarti D. (1951) Ind. Med Gaz. 86(3): 96-7. 2. Tsai H.R., et al. (2004) Eur J Pharmacol. 498: 45-52. 3. Rajagopal S., et al. (2003) J Exp. Ther. Oncol. 3: 147-158. |
Product Images
Chemical structure of Andrographolide (SIH-220), a Induces mitochondrial -mediated apoptosis in lymphoma cells. CAS #: 5508-58-7. Molecular Formula: C20H30O5. Molecular Weight: 350.45 g/mol.
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