Methyltransferase inhibitor

Catalog No. SIH-351

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CAS No. 28097-03-2
Molecular Forumla C30H28N6O6S4

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Product Name Chaetocin

Methyltransferase inhibitor

Purity >99% (TLC), NMR conforms
CAS No. 28097-03-2
Molecular Formula C30H28N6O6S4
Molecular Weight 696.9


Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol
Source Synthetic
Appearance Lyophilized Solid
InChI InChI=1S/C30H28N6O6S4/c1-33-21(39)27-11-25(15-7-3-5-9-17(15)31-19(25)35(27)23(41)29(33,13-37)45-43-27)26-12-28-22(40
Safety Phrases Classification: Harmful- Harmful by inhalation, in contact with skin, and if swallowed. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Precautionary Statements: P280 Wear protective gloves/protective clothing/eye protection/face protection. P301+P312- IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P304+P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. Hazard Statements: H302- Harmful if swallowed H312- Harmful in contact with skin H332- Harmful if inhaled
Cite This Product Chaetocin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-351)

Biological Description

Alternative Names 2,​2',​3S,​3'S,​5aR,​5'aR,​6,​6'-​octahydro-​3,​3'-​bis(hydroxymethyl)-​2,​2'-​dimethyl-​[10bR,​10'bR(11aS,​11'aS)-​bi-​3,​11a-​epidithio-​11aH-​pyrazino[1',​2':1,​5]pyrrolo[2,​3-​b]indole]-​1,​1',​4,​4'-​tetrone
Research Areas Cancer, Cell Signaling, Epigenetics
PubChem ID 161591
Scientific Background Inhibits the lysine methyltransferase SU (VAR)3-9. Displays antimyeloma activity in IL-6-dependent myeloma cell lines. Cell permeable.
References 1. Greiner D., et al. (2005) Nat Chem Biol. 1: 143. 2. Isham, C.R., et al. (2007) Blood. 109: 2579.

Product Images

<p>Chemical structure of Chaetocin (SIH-351), a Lys methyltransferase inhibitor. CAS #: 28097-03-2    . Molecular Formula: C30H28N6O6S4. Molecular Weight: 696.9 g/mol.</p>

Chemical structure of Chaetocin (SIH-351), a Lys methyltransferase inhibitor. CAS #: 28097-03-2 . Molecular Formula: C30H28N6O6S4. Molecular Weight: 696.9 g/mol.

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