Chaetocin

Methyltransferase inhibitor

Catalog No. SIH-351

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CAS No. 28097-03-2
Molecular Forumla C30H28N6O6S4

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Overview

Product Name Chaetocin
Description

Methyltransferase inhibitor

Purity >99% (TLC), NMR conforms
CAS No. 28097-03-2
Molecular Formula C30H28N6O6S4
Molecular Weight 696.9

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol
Source Synthetic
Appearance Lyophilized Solid
SMILES O=C1N4C2(SSC1(N(C2=O)C)CO)CC5(c3ccccc3NC45)C98cc(NC9N6C(=O)C7(SSC6(C(=O)N7C)C8)CO)cccc
InChI InChI=1S/C30H28N6O6S4/c1-33-21(39)27-11-25(15-7-3-5-9-17(15)31-19(25)35(27)23(41)29(33,13-37)45-43-27)26-12-28-22(40
InChIKey PZPPOCZWRGNKIR-UHFFFAOYSA-N
Safety Phrases Classification: Harmful- Harmful by inhalation, in contact with skin, and if swallowed.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Precautionary Statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312- IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304+P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P501 Dispose of contents/container in accordance with local/regional/national/international regulations.
Hazard Statements:
H302- Harmful if swallowed
H312- Harmful in contact with skin
H332- Harmful if inhaled
Cite This Product Chaetocin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-351)

Biological Description

Alternative Names 2,?2',?3S,?3'S,?5aR,?5'aR,?6,?6'-?octahydro-?3,?3'-?bis(hydroxymethyl)-?2,?2'-?dimethyl-?[10bR,?10'bR(11aS,?11'aS)-?bi-?3,?11a-?epidithio-?11aH-?pyrazino[1',?2':1,?5]pyrrolo[2,?3-?b]indole]-?1,?1',?4,?4'-?tetrone
Research Areas Cancer, Cell Signaling, Epigenetics
PubChem ID 161591
Scientific Background Inhibits the lysine methyltransferase SU (VAR)3-9. Displays antimyeloma activity in IL-6-dependent myeloma cell lines. Cell permeable.
References 1. Greiner D., et al. (2005) Nat Chem Biol. 1: 143.
2. Isham, C.R., et al. (2007) Blood. 109: 2579.

Product Images

Chemical structure of Chaetocin (SIH-351), a Lys methyltransferase inhibitor. CAS #: 28097-03-2 . Molecular Formula: C30H28N6O6S4. Molecular Weight: 696.9 g/mol.

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