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| Product Name | DMPQ Dihydrochloride |
| Description |
PDGFRβ kinase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 137206-97-4 |
| Molecular Formula | C16H16ClN2O2 |
| Molecular Weight | 339.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in water |
| Source | Synthetic |
| Appearance | White to beige solid |
| SMILES | C1=CC(=CC=N1)C2=CC3=C(N=C2)C=C(C=C3OC)OC |
| InChI | InChI=1S/C16H14N2O2.2ClH/c1-19-13-8-15-14(16(9-13)20-2)7-12(10-18-15)11-3-5-17-6-4-11;;/h3-10H,1-2H3;2*1H |
| InChIKey | YBBAOKYVJCNJIV-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 4) Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. |
| Cite This Product | DMPQ Dihydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-441) |
Biological Description
| Alternative Names | 5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 45073427 |
| Scientific Background | DMPQ dihydrochloride is a potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ). It displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C. |
| References | 1. Dolle R.E., et al. (1994) J. Med. Chem. 37(17): 2627–2629. |
Product Images
Chemical structure of DMPQ Dihydrochloride (SIH-441), a PDGFRbeta kinase inhibitor. CAS #: 137206-97-4. Molecular Formula: C16H16ClN2O2. Molecular Weight: 339.2 g/mol.
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