FK506

FKBP inhibitor

Catalog No. SIH-214

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CAS No. 104987-11-3
Molecular Formula C44H69HO12
SKU: SIH-214 Categories: ,

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SIH-214_FK506_Chemical_Structure.png
Product Name FK506
Description

FKBP inhibitor

Purity >98%
CAS No. 104987-11-3
Molecular Formula C44H69HO12
Molecular Weight 804.02
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in ethanol, and to 100 mM in DMSO
Source Synthetic
Appearance White Solid
SMILES CCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OCCCC2=CN=CC=C2
InChI InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)4
InChIKey QJJXYPPXXYFBGM-LFZNUXCKSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H301
Precautionary Phrases:
P301 + P310
Cite This Product FK506 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-214)

Biological Description

Alternative Names 3-(3-Pyridinyl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)prolinate, Tacrolimus, Fujimycin
Research Areas Apoptosis, Cancer
PubChem ID 445643
Scientific Background FK506 or Fujimycin or Tacrolimus, is an immunosuppressant. It is mainly used after allogeneic organ transplants, but can also be used topically in the treatment of eczema, uveitis and vitiligo (1). It is a macrolide that prevents the dephosphorylation of NF-AT. It reduces peptidyl-prolyl isomerase activity by binding to FKBP12 creating a new complex that interacts with and inhibits calcineurin (2, 3).
References 1. Nanette B., et al. (2004) J Am Acad Derm. 51(5): 760-766.
2. Ganong W.F., Review of Medical Physiology (22nd ed.) Lange Medical Books. P.530
3. Liu J. Lane W., Friedman J, Weissman I and Schreiber S. (1991) Cell. 66(4): 807-815

Product Images

<p>Chemical structure of FK506 (SIH-214), a FKBP inhibitor. CAS #: 109581-93-3. Molecular Formula: C44H69NO12 · H2O. Molecular Weight: 804.02 g/mol.</p>

Chemical structure of FK506 (SIH-214), a FKBP inhibitor. CAS #: 109581-93-3. Molecular Formula: C44H69NO12 · H2O. Molecular Weight: 804.02 g/mol.

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