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| Product Name | FTY720 Hydrochloride |
| Description |
S1P receptor ligand |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 162359-56-0 |
| Molecular Formula | C19H34ClNO2 |
| Molecular Weight | 343.9 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Agonist |
| Solubility | Soluble to 100 mg/ml in DMSO or to 40 mg/ml in ethanol (warmed) |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl |
| InChI | InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H |
| InChIKey | SWZTYAVBMYWFGS-UHFFFAOYSA-N |
| Safety Phrases |
Classification: D2B Toxic Material Causing Other Toxic Effects Moderate skin irritant Moderate eye irritant Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statement(s): H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H412 Harmful to aquatic life with long lasting effects. Precautionary statement(s): P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P273 Avoid release to the environment. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| Cite This Product | FTY720 Hydrochloride (StressMarq Biosciences, Canada, Cat # SIH-523) |
Biological Description
| Alternative Names | 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol,hydrochloride; Fingolimod |
| Research Areas | Cell Signaling, Neurodegeneration, Neuroscience, Parkinson's Disease |
| PubChem ID | 107969 |
| Scientific Background | FTY720 is a potent sphingosine 1-phosphate receptors (S1P) agonist once it is phosphorylated by sphingosine kinase. This causes lymphocytes to be sequestered in lymph nodes, which also makes FTY720 an immune modulating drug for multiple sclerosis. It has been shown to stimulate neuronal gene expression, axonal growth and regeneration (3). And recently FTY720 has also been shown to reduce α-Synuclein pathology in parkinsonian GM2+/- Mice (4). |
| References |
1. Wolf A., et al. (2009) J Immunol. 183(6): 3751-60. 2. Brinkmann V., et al. (2002) J Biol Chem. 277(24): 21453-7. 3. Anastasiadou S., and Knoll B. (2016) Exp. Neurol. 279: 243-260. 4. Vidal-Martinez G., at al. (2019) Neuroscience. 411: 1-10. |
Product Images
Chemical structure of FTY720 Hydrochloride (SIH-523), a Sphingosine 1-phosphate receptor agonist. CAS #: 162359-56-0. Molecular Formula: C19H34ClNO2. Molecular Weight: 343.9 g/mol.
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