Galanthamine HBr

Acetylcholinesterase inhibitor

Catalog No. SIH-530

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CAS No. 1953-04-4
Molecular Formula C17H22BrNO3
SKU: SIH-530 Categories: ,

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SIH-530-Galanthamine-HBr-Chemical-Structure.png
Product Name Galanthamine HBr
Description

Acetylcholinesterase inhibitor

Purity >97% (HPLC); NMR (Conforms)
CAS No. 1953-04-4
Molecular Formula C17H22BrNO3
Molecular Weight 368.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Product Type Inhibitor
Solubility Soluble in water (12 mg/ml) or in DMSO (10 mg/ml)
Source Synthetic
Appearance White powder
SMILES [Br-].COc1ccc2CN(C)CC[C@@]34C=C[C@H](O)C[C@@H]3Oc1c24.[H+]
InChI 1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1
InChIKey QORVDGQLPPAFRS-XPSHAMGMSA-N
Safety Phrases Classification:
D1B Toxic Material Causing Immediate and Serious Toxic Effects - Toxic by ingestion

Hazard statement(s):
H301 Toxic if swallowed.

Precautionary statement(s):
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
Cite This Product Galanthamine HBr (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-530)

Biological Description

Alternative Names Galantamine hydrobromide, Galantamine HBr, Galanthamine hydrobromide, Galanthamine, Galanthamine hydrogen bromide, SPECTRUM1501202, 1,2,3,4,6,7,7a,11c-Octahydro-9-methoxy-2-methyl-benzofuro(4,3,2-efg)(2)benzazocin-6-ol HBr, LS-185021, Galanthamine, Nivalin, Reminyl, Jilkon hydrobromide, Lycoremine hydrobromide
Research Areas Alzheimer's Disease, Apoptosis, Cancer, Neurodegeneration, Neuroscience
PubChem ID 121587
Scientific Background Galantamine hydrobromide is a long-acting, active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. It prevents β-amyloid-induced apoptosis in SH-SY5Y. Long-term administration in a mouse model of Alzheimer's disease reduces amyloid precursor protein deposition and neurodegeneration in these mice.

Product Images

<p>Chemical structure of Galanthamine HBr (SIH-530), a Acetylcholinesterase inhibitor. CAS #: 1953-04-4. Molecular Formula: C17H22BrNO3. Molecular Weight: 368.3 g/mol.</p>

Chemical structure of Galanthamine HBr (SIH-530), a Acetylcholinesterase inhibitor. CAS #: 1953-04-4. Molecular Formula: C17H22BrNO3. Molecular Weight: 368.3 g/mol.

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