GW 441756

NGFR kinase inhibitor

Catalog No. SIH-450

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CAS No. 504433-23-2
Molecular Formula C17H13N3O
SKU: SIH-450 Categories: ,

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SIH-450_GW-441756_Chemical_Structure.png
Product Name GW 441756
Description

NGFR kinase inhibitor

Purity >99%
CAS No. 504433-23-2
Molecular Formula C17H13N3O
Molecular Weight 275.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 15 mM in DMSO
Source Synthetic
Appearance Red solid
SMILES CN1C=C(C2=CC=CC=C21)/C=C3/C4=C(C=CC=N4)NC3=O
InChI InChI=1S/C17H13N3O/c1-20-10-11(12-5-2-3-7-15(12)20)9-13-16-14(19-17(13)21)6-4-8-18-16/h2-10H,1H3,(H,19,21)/b13-9-
InChIKey NXNQLECPAXXYTR-LCYFTJDESA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product GW 441756 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-450)

Biological Description

Alternative Names 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 9943465
Scientific Background GW 441756 is a potent and selective NGF receptor tyrosine kinase A (TrkA) inhibitor. Specifically, it is shown to block apoptosis and cell death induced by TrkA. GW-441756 displays > 100-fold selectivity over a range of other kinases.
References 1. Wood E.R., et al. (2004) Bioorganic & Med. Chem. Ltr. 14(4): 953–957.
2. Jung E.J., Kim C.W., & Kim D.R. (2008) Exp. Mol. Med. 40(3): 276–285.

Product Images

<p>Chemical structure of GW 441756 (SIH-450), a NGFR kinase inhibitor. CAS #: 504433-23-2. Molecular Formula: C17H13N3O. Molecular Weight: 275.3 g/mol.</p>

Chemical structure of GW 441756 (SIH-450), a NGFR kinase inhibitor. CAS #: 504433-23-2. Molecular Formula: C17H13N3O. Molecular Weight: 275.3 g/mol.

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