Itraconazole

Cytochrome P450 inhibitor

Catalog No. SIH-543

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CAS No. 84625-61-6
Molecular Formula C35H38Cl2N8O4
SKU: SIH-543 Categories: ,

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SIH-543-Itraconazole-Chemical-Structure.png
Product Name Itraconazole
Description

Cytochrome P450 inhibitor

Purity >98%
CAS No. 84625-61-6
Molecular Formula C35H38Cl2N8O4
Molecular Weight 705.6
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in chloroform (50 mg/ml)
Source Synthetic
SMILES CCC(C)N1N=CN(C1=O)c2ccc(cc2)N3CCN(CC3)c4ccc(OC[C@H]5CO[C@@](Cn6cncn6)(O5)c7ccc(Cl)cc7Cl)cc4
InChI 1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,1
InChIKey VHVPQPYKVGDNFY-ZPGVKDDISA-N
Safety Phrases Classification:
D1B Toxic Material Causing Immediate and Serious Toxic Effects - Toxic by ingestion
D2A Very Toxic Material Causing Other Toxic Effects - Teratogen
D2B Toxic Material Causing Other Toxic Effects - Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant

Hazard statement(s):
H302 Harmful if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.

Precautionary statement(s):
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Cite This Product Itraconazole (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-543)

Biological Description

Alternative Names Itraconazole, 84625-61-6, Sporanox, ITRAZOLE, Itraconazolum, Oriconazole, R51211, Sporanox, 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one
Research Areas Angiogenesis, Autophagy, Cancer, Cardiovascular System, Growth Factors
PubChem ID 3793
Scientific Background Itraconazole is an triazol antifungal agent. It inhibits P-450 dependent enzymes, which results in the inhibition of ergosterol synthesis.

Product Images

<p>Chemical structure of Itraconazole (SIH-543), a Cytochrome P450 inhibitor. CAS #: 84625-61-6. Molecular Formula: C35H38Cl2N8O4. Molecular Weight: 705.6 g/mol.</p>

Chemical structure of Itraconazole (SIH-543), a Cytochrome P450 inhibitor. CAS #: 84625-61-6. Molecular Formula: C35H38Cl2N8O4. Molecular Weight: 705.6 g/mol.

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