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| Product Name | KB-R7943 mesylate |
| Description |
TRPC channel blocker |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 182004-65-5 |
| Molecular Formula | C16H17N3O3S•CH3SO3H |
| Molecular Weight | 427.29 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | CS(=O)(=O)O.C1=CC(=CC=C1CCSC(=N)N)OCC2=CC=C(C=C2)[N+](=O)[O-] |
| InChI | InChI=1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4) |
| InChIKey | WGIKEBHIKKWJLG-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | KB-R7943 mesylate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-312) |
Biological Description
| Alternative Names | 2-{4-[(4-Nitrobenzyl)oxy]phenyl}ethyl carbamimidothioate methanesulfonate (1:1) |
| Research Areas | Ion Channels, Neuroscience |
| PubChem ID | 9823846 |
| Scientific Background | KN-R9743 mesylate is a potent selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger. It also inhibits the mitochondrial Ca2+ uniporter. It does not affect Na+ dependent transport systems or ionotropic glutamate receptors. |
| References |
1. Hoyt K.R., Arden S.R., Aizenman E. and Reynolds I.J. (1998) Mol Pharmacol. 53(4): 742-749. 2. Schroder U.H., Breder J, Sabelhaus C.F., Reymann K.G. (1999) Neuropharm. 38(2): 319-321. 3. Watano T., Harada Y., Harada K., Nishimura N. (1999) Br J Pharmacol. 127(8): 1846-1850. |
Product Images
Chemical structure of KB-R7943 mesylate (SIH-312), a TRPC channel blocker. CAS #: 182004-65-5. Molecular Formula: C16H17N3O3S.CH3SO3H. Molecular Weight: 427.29 g/mol.
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