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| Product Name | NVPBEZ235 |
| Description |
PI 3-kinase inhibitor |
| Purity | >97% |
| CAS No. | 915019-65-7 |
| Molecular Formula | C30H23N5O |
| Molecular Weight | 469.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in chloroform (1 mg/ml), 1-methyl-2-pyrrolidnone (2 mg/ml at 75 °C), DMSO (1.33 mg/ml), and DMF (10 mg/ml at 75 °C) |
| Source | Synthetic |
| Appearance | Crystalline solid |
| SMILES | CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5 |
| InChI | InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3 |
| InChIKey | JOGKUKXHTYWRGZ-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Skin irritation (Category 2) Eye irritation (Category 2) Respiratory tract irritation (Category 3) Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302+H312 Harmful if swallowed or in contact with skin. H315 Causes skin irritation. H319 Causes serious eye irritation. H332 Harmful if inhaled. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash hands thoroughly after handling. P301+P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302+P352 IF ON SKIN: Wash with plenty of soap and water. P304+P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P332+P313 If skin irritation occurs: Get medical advice/attention. P337+P313 If eye irritation persists: Get medical advice/attention. P363 Wash contaminated clothing before reuse. P501 Dispose of contents/container to an approved waste disposal plant. |
| Cite This Product | NVPBEZ235 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-465) |
Biological Description
| Alternative Names | 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-α,α-dimethyl-benzeneacetonitrile |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 11977753 |
| Scientific Background | NVPBEZ235 is a specific PI 3-kinase (PI3K) tyrosine kinase inhibitor, which shows dual PI3K/mTOR inhibition. NVPBEZ235 has also been shown to inhibit ATR. It has demonstrated antiproliferative activity against tumor cell lines in animal models of cancer. |
| References |
1. Yasumizu Y., et al. (2014) J. Urology. 191(1): 227–234. 2. Shortt J., et al. (2013) Blood. 121(15): 2964–2974. |
Product Images
Chemical structure of NVPBEZ235 (SIH-465), a PI 3-kinase inhibitor. CAS #: 915019-65-7. Molecular Formula: C30H23N5O. Molecular Weight: 469.5 g/mol.
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