SB216763

GSK-3 kinase inhibitor

Catalog No. SIH-510

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CAS No. 280744-09-4
Molecular Formula C19H12Cl2N2O2
SKU: SIH-510 Categories: ,

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SIH-510_SB-216763_Chemical_Structure.png
Product Name SB216763
Description

GSK-3 kinase inhibitor

Purity >98% (TLC)
CAS No. 280744-09-4
Molecular Formula C19H12Cl2N2O2
Molecular Weight 371.2
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (>25 mg/ml)
Source Synthetic
Appearance Orange solid
SMILES CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C(C=C(C=C4)Cl)Cl
InChI InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
InChIKey JCSGFHVFHSKIJH-UHFFFAOYSA-N
Safety Phrases Classification:
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.

Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
P321 Specific treatment (see supplemental first aid instructions on this label).
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P362 Take off contaminated clothing and wash before reuse.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product SB216763 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-510)

Biological Description

Alternative Names SB 216763, 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 176158
Scientific Background SB216763 is a potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor. It inhibits both human GSK-3α and GSK-3β. SB216763 has been shown to stimulate glycogen synthesis in human liver cells and mimic other actions of insulin. SB216763 is cell-permeable and ATP-competitive.
References 1. Culbert A.A., et al. (2001) FEBS Letters. 507(3): 288–294.
2. Coghlan M.P., et al. (2000) Chem. Biol. 7(10): 793–803.

Product Images

<p>Chemical structure of SB216763 (SIH-510), a GSK-3 kinase inhibitor. CAS #: 280744-09-4. Molecular Formula: C19H12Cl2N2O2. Molecular Weight: 371.2 g/mol.</p>

Chemical structure of SB216763 (SIH-510), a GSK-3 kinase inhibitor. CAS #: 280744-09-4. Molecular Formula: C19H12Cl2N2O2. Molecular Weight: 371.2 g/mol.

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