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| Product Name | SB431542 |
| Description |
ALK4,5 and 7 kinase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 301836-41-9 |
| Molecular Formula | C22H16N4O3 |
| Molecular Weight | 384.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 10 mM in ethanol and to 100 mM in DMSO |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5 |
| InChI | InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26) |
| InChIKey | FHYUGAJXYORMHI-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | SB431542 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-511) |
Biological Description
| Alternative Names | SB 431542, 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 4521392 |
| Scientific Background | SB431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor, activin receptor-like kinases. It has been shown to inhibit ALK4, 5, and 7. |
| References | 1. Laping N.J., et al. (2002) Mol. Pharm. 62(1): 58–64. |
Product Images
Chemical structure of SB431542 (SIH-511), a ALK4,5 and 7 kinase inhibitor. CAS #: 301836-41-9. Molecular Formula: C22H16N4O3. Molecular Weight: 384.4 g/mol.
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