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| Product Name | SRPIN340 |
| Description |
SR kinase inhibitor |
| Purity | >98% |
| CAS No. | 218156-96-8 |
| Molecular Formula | C18H18F3N3O |
| Molecular Weight | 349.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl |
| Source | Synthetic |
| Appearance | Off-white solid |
| SMILES | C1CCN(CC1)C2=C(C=C(C=C2)C(F)(F)F)NC(=O)C3=CC=NC=C3 |
| InChI | InChI=1S/C18H18F3N3O/c19-18(20,21)14-4-5-16(24-10-2-1-3-11-24)15(12-14)23-17(25)13-6-8-22-9-7-13/h4-9,12H,1-3,10-11H2,(H,23,25) |
| InChIKey | DWFGGOFPIISJIT-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | SRPIN340 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-514) |
Biological Description
| Alternative Names | N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 2797577 |
| Scientific Background | SRPIN340 is a selective inhibitor of serine–arginine protein kinases (SRPK). It has been shown to inhibit SRPK1, as well as, SRPK2, at higher concentrations. SRPIN340 is ATP-competitive. |
| References | 1. Karakama Y., et al. (2010). Antimicrobial Agents Chemo. 54(8): 3179–3186. |
Product Images
Chemical structure of SRPIN340 (SIH-514), a SR kinase inhibitor. CAS #: 218156-96-8. Molecular Formula: C18H18F3N3O. Molecular Weight: 349.4 g/mol.
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Based on validation through cited publications.