Teprenone

Name: Teprenone
SKU: SIH-526
Availability: InStock

HSP70 Inducer

Catalog No. SIH-526

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CAS No.	6809-52-5
Molecular Formula	C23H38O

SKU: SIH-526 Categories: Inducer, Small Molecules

Product Name	Teprenone
Description	HSP70 Inducer
Purity	>95% (GC)
CAS No.	6809-52-5
Molecular Formula	C₂₃H₃₈O
Molecular Weight	330.6
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inducer
Solubility	Soluble in DMSO (30 mg/ml)
Source	Synthetic
Appearance	Colorless Oil
SMILES	CC(=CCC/C(=C/CC/C(=C/CC/C(=C/CCC(=O)C)/C)/C)/C)C
InChI	InChI=1S/C23H38O/c1-19(2)11-7-12-20(3)13-8-14-21(4)15-9-16-22(5)17-10-18-23(6)24/h11,13,15,17H,7-10,12,14,16,18H2,1-6H3/b20-13+,21-15+,22-17+
InChIKey	HUCXKZBETONXFO-NJFMWZAGSA-N
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product	Teprenone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-526)

Alternative Names	Geranylgeranylacetone, GGA, 6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one
Research Areas	Cancer, Cell Signaling, Heat Shock, Neuroscience
PubChem ID	5282199
Scientific Background	Teprenone can induce expression of HSP70, HSPB8, and HSPB1. Induction of HSP70 expression is protective against the development of various diseases, such as inflammatory bowel disease, hypoxic/ischemic brain injury and spinal and bulbar muscular atrophy (cytoprotective and anti-inflammatory effects) (1, 2). Reports indicate that Teprenone protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression (2). Other studies have shown that it induces expression of HSPB8 and HSPB1 and reduces the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice (3, 4).
References	1. Kobayashi T., Ohta Y., Yoshino J and Nakazawa S. (2001) Pharmacol Res. 43(1): 23-30. 2. Sambroski P., Grzymislawski M. (2015) Adv Clin Med. 24(3): 525-530. 3. Marunouchi T., Inomata S., Sanbe A., Takagi N., Tanonaka K. (2014) Eur J Pharmacol. 730: 1401-47. 4. Sanbe A., et al. (2009) PLoS One. 4(4): e5351.

Chemical structure of Teprenone (SIH-526), a HSP70 Inducer. CAS #: 6809-52-5. Molecular Formula: C23H38O. Molecular Weight: 330.6 g/mol.

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