Teprenone

HSP70 Inducer

Catalog No. SIH-526

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CAS No. 6809-52-5
Molecular Forumla C23H38O

USD $65.00USD $195.00

SKU: SIH-526 Categories: , .

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Overview

Product Name Teprenone
Description

HSP70 Inducer

Purity >95% (GC)
CAS No. 6809-52-5
Molecular Formula C23H38O
Molecular Weight 330.6

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inducer
Solubility Soluble in DMSO (30 mg/ml)
Source Synthetic
Appearance Colorless Oil
SMILES CC(=CCC/C(=C/CC/C(=C/CC/C(=C/CCC(=O)C)/C)/C)/C)C
InChI InChI=1S/C23H38O/c1-19(2)11-7-12-20(3)13-8-14-21(4)15-9-16-22(5)17-10-18-23(6)24/h11,13,15,17H,7-10,12,14,16,18H2,1-6H3/b20-13+,21-15+,22-17+
InChIKey HUCXKZBETONXFO-NJFMWZAGSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product Teprenone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-526)

Biological Description

Alternative Names Geranylgeranylacetone, GGA, 6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one
Research Areas Cancer, Heat Shock, Cell Signaling, Neuroscience
PubChem ID 5282199
Scientific Background Teprenone can induce expression of HSP70, HSPB8, and HSPB1. Induction of HSP70 expression is protective against the development of various diseases, such as inflammatory bowel disease, hypoxic/ischemic brain injury and spinal and bulbar muscular atrophy (cytoprotective and anti-inflammatory effects) (1, 2). Reports indicate that Teprenone protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression (2). Other studies have shown that it induces expression of HSPB8 and HSPB1 and reduces the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice (3, 4).
References 1. Kobayashi T., Ohta Y., Yoshino J and Nakazawa S. (2001) Pharmacol Res. 43(1): 23-30.
2. Sambroski P., Grzymislawski M. (2015) Adv Clin Med. 24(3): 525-530.
3. Marunouchi T., Inomata S., Sanbe A., Takagi N., Tanonaka K. (2014) Eur J Pharmacol. 730: 1401-47.
4. Sanbe A., et al. (2009) PLoS One. 4(4): e5351.

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