Trichostatin A

HDAC inhibitor

Catalog No. SIH-254

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CAS No. 58880-19-6
Molecular Formula C17H22N2O3
SKU: SIH-254 Categories: ,

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SIH-254_Trichostatin_A_Chemical_Structure.png
Product Name Trichostatin A
Description

HDAC inhibitor

Purity >98%
CAS No. 58880-19-6
Molecular Formula C17H22N2O3
Molecular Weight 302.37
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 10 mM in ethanol and to 50 mM in DMSO
Source Synthetic
Appearance Beige Solid
SMILES C[C@H](/C=C(C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
InChI InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+
InChIKey RTKIYFITIVXBLE-WKWSCTOISA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed
R68 - Possible risk of irreversible effects
Hazard Phrases:
H302-H312-H315-H317-H319-H332-H335
Precautionary Phrases:
P261-P280-P305 + P351 + P338
Cite This Product Trichostatin A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-254)

Biological Description

Alternative Names (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, HDAC Inhibitors
PubChem ID 444732
Scientific Background Trichostatin A is an antifungal and selectively inhibits the class I and II mammalian histon deacetlyase families of enzymes (1). TSA inhibits the eukayotic cell cycle during the beginning of the growth stage. It can be used to alter gene expression but interfering with the removal of acetyl groups thereby altering the ability of DNA transcription factors to access the DNA inside chromatin (2). It also has anti-cancer properties (3).
References 1. Vanhaecke T., Papeleu P., Elaut G., Rogiers V. (2004) Curr Med Chem. 11(12): 1629-1643.
2. Yoshida, et al. (1990) J Biol Chem. 165: 17174.
3. Drummond D.C., et al. (2005) Annu Rev Pharmacol Toxicol. 45: 495-528.

Product Images

<p>Chemical structure of Trichostatin A (SIH-254), a Histone deacetylase inhibitor. CAS #: 58880-19-6. Molecular Formula: C17H22N2O3. Molecular Weight: 302.37 g/mol.</p>

Chemical structure of Trichostatin A (SIH-254), a Histone deacetylase inhibitor. CAS #: 58880-19-6. Molecular Formula: C17H22N2O3. Molecular Weight: 302.37 g/mol.

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