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| Product Name | Vinblastine sulfate |
| Description |
Cell cycle blocker |
| Purity | >98% |
| CAS No. | 143-67-9 |
| Molecular Formula | C46H58N4O9•H2SO4 |
| Molecular Weight | 909.1 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO, methanol or water (25 mg/ml). |
| Source | Synthetic |
| Appearance | White powder. |
| SMILES | [C@@]178[C@@H](N(C2=C1C=C(C(=C2)OC)[C@@]5(C3=C(C4=C([NH]3)C=CC=C4)CCN6C[C@@H](C5)C[C@](O)(C6)CC)C(OC)=O)C)[C@](O)([C@H](OC |
| InChI | InChI=1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3) |
| InChIKey | KDQAABAKXDWYSZ-PNYVAJAMSA-N |
| Safety Phrases |
Classification: D1B- Toxic Material Causing Immediate and Serious Toxic Effects, Toxic by ingestion, D2B- Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate eye irritant, Mutagen Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302- Harmful if swallowed. H315- Causes skin irritation. H318- Causes serious eye damage. H335- May cause respiratory irritation. Precautionary statements: P261- Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P280- Wear protective gloves/ eye protection/ face protection. P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| Cite This Product | Vinblastine sulfate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-407) |
Biological Description
| Alternative Names | Vincaleukoblastine |
| Research Areas | Autophagy, Cancer |
| PubChem ID | 5388983 |
| Scientific Background | Vinblastine sulfate is used clinically as a cancer chemotherapeutic agent. It disrupts normal microtubule assembly. Vinblastine also inhibits autophagy by obstructing autophagosome maturation and by stopping the fusion event of autophagosomes with lysosomes. |
| References |
1. Veldhoen R.A., et al. (2013) Oncogene. 32(6): 736-46. 2. Adiseshaiah P.P., et al. (2013) Cancer Lett. 337(2): 254-65. |
Product Images
Chemical structure of Vinblastine sulfate (SIH-407), a Microtubule assembly inhibitor. CAS #: 143-67-9. Molecular Formula: C46H58N4O9 . H2SO4. Molecular Weight: 909.1 g/mol.
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