|Shipping Temperature||Shipped Ambient|
|Solubility||Soluble in DMSO|
|Safety Phrases||Classification: Caution: Substance not yet fully tested.
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
|Cite This Product||YM-08 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-122)|
|Alternative Names||(2Z,5E)-3-ethyl-5-(3-methyl-1,3-benzothiazol-2-ylidene)-2-(pyridin-2-ylmethylidene)-1,3-thiazolidin-4-one, YM8, YM08|
|Research Areas||Cancer, Heat Shock|
|Scientific Background||YM-08 is a Heat Shock Protein 70 (Hsp70) inhibitor that is blood-brain barrier permeable. YM-08 is a neutral derivative of the Hsp70 inhibitor MKT-077. MKT-077 reduces tau levels in cellular models, but it doesn′t penetrate the blood brain barrier. Although YM-08 was somewhat less effective than MKT-077 in anti-tau and anticancer assays, it selectively reduced pathogenic tau in brain slices, which MKT-077 did not. Furthermore,YM-08 was not retained in the kidney leading one to speculate that it would not have the nephrotoxicity that was a problem for MKT-077 in clinical trials. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.|
|References||1. Miyata, Y. et al. 2013 ACS Chemical Neuroscience Jun 19;4(6):930-9. doi: 10.1021/cn300210g|
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