Hsp70 Inhibitor

Catalog No. SIH-122

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Molecular Forumla C19H17N3OS2

USD $165.00USD $330.00

SKU: SIH-122 Categories: , .

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Product Name YM-08

Hsp70 Inhibitor

Purity >99% (HPLC)
Molecular Formula C19H17N3OS2
Molecular Weight 367.49


Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO
Source Synthetic
Appearance Yellow-orange solid
SMILES O=C2C(SC(=Cc1ncccc1)N2CC)=C3Sc4ccccc4N3C
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product YM-08 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-122)

Biological Description

Alternative Names (2Z,5E)-3-ethyl-5-(3-methyl-1,3-benzothiazol-2-ylidene)-2-(pyridin-2-ylmethylidene)-1,3-thiazolidin-4-one, YM8, YM08
Research Areas Cancer, Heat Shock
Scientific Background YM-08 is a Heat Shock Protein 70 (Hsp70) inhibitor that is blood-brain barrier permeable. YM-08 is a neutral derivative of the Hsp70 inhibitor MKT-077. MKT-077 reduces tau levels in cellular models, but it doesn′t penetrate the blood brain barrier. Although YM-08 was somewhat less effective than MKT-077 in anti-tau and anticancer assays, it selectively reduced pathogenic tau in brain slices, which MKT-077 did not. Furthermore,YM-08 was not retained in the kidney leading one to speculate that it would not have the nephrotoxicity that was a problem for MKT-077 in clinical trials. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
References 1. Miyata, Y. et al. 2013 ACS Chemical Neuroscience Jun 19;4(6):930-9. doi: 10.1021/cn300210g

Product Images

Chemical structure of YM-08 (SIH-122), a Hsp70 Inhibitor. CAS #: N/A. Molecular Formula: C19H17N3OS2. Molecular Weight: 367.49 g/mol.

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