Within the neuronal synapse, the postsynaptic membrane receives signals sent from the presynaptic terminal. The signals are received via membrane bound receptors which bind to the neurotransmitters present in the synaptic cleft.
Binding of a neurotransmitter to an ionotropic receptor will lead to the opening of an ion channel, allowing ions to flow into or out of the cell. The flow of ions alters the postsynaptic membrane potential.
If a neurotransmitter binds to a metabotropic receptor, a signally pathway is activated through the use of second messengers.
The postsynaptic membrane contains a dense group of hundreds of specialized proteins known collectively as the postsynaptic density (PSD). The PSD has been shown to contain postsynaptic density-95 (PSD95), neuroligin, SAP102, SAPAP, SHANK, and calcium/calmodulim-dependent protein kinase II.
Immunostaining of the PSD through known protein targets enables neuroscientists to ask and answer complex research questions about how messages are sent and received within the brain. We are dedicated to developing cutting edge postsynaptic markers to aid in the study of neuroscience, including monoclonal antibodies, polyclonal antibodies, and antibody conjugates.