Hereditary Spastic Paraplegia
Hereditary Spastic Paraplegia, also known as hereditary spastic paraparesis , is a genetic disease characterized by progressive lower limb stiffness and contraction. These symptoms are a result of dysfunction of the long nerves in the limbs, which are unable to transport proteins through the cell.
Mutations in the gene encoding the receptor expression-enhancing protein 1 (REEP1) have been found in 6% of Hereditary Spastic Paraplegia cases. REEP1 is widely expressed and localizes to the endoplasmic reticulum and mitochondrial membrane. It has been found to be involved in long-term axonal maintenance.
Hereditary spastic paraplegia research requires a great diversity of life science products to investigate methods for diagnosis and treatment. We are dedicated to developing cutting edge research products to aid in the study of hereditary spastic paraplegia including monoclonal antibodies, polyclonal antibodies, antibody conjugates, proteins, immunoassays, and small molecule inhibitors.