HSP Modulators: 115-7c

115-7c Chemical Structure HSP70 inhibitors and modulators115-7c

Heat Shock Protein 70/HSP70 Activator

StressMarq catalog# SIH-123

Molecular Formula: C23H22Cl2N2O5

Molecular Weight: 477.34 g/mol

Research Areas: Cancer Research, Heat Shock

Alternative Names: 4-(5-((benzyloxy)carbonyl)-4-(2,4-dichlorophenyl)-6-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)butanoic acid

 

Biological Description

115-7c activates Hsp70 ATPase turnover rate and promotes Hsp70 substrate refolding. It binds to the IIA subdomain of DnaK and promotes the DnaK-DnaJ complex. Equivalent with SW02.

 

References:

  1. Wisén S, et al. Binding of a Small Molecule at a Protein–Protein Interface Regulates the Chaperone Activity of Hsp70–Hsp40. ACS Chem Biol. 2010; 5(6): 611–622.
  2. Jinwal UK, et al. Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability. J Neurosci. 2009; 29(39): 12079–12088.
  3. Chafekar SM, et al. Pharmacological Tuning of Heat Shock Protein 70 Modulates Polyglutamine Toxicity and Aggregation. ACS Chem Biol. 2012; 7(9): 1556–1564.
  4. Walter GM, et al. Ordered Assembly of Heat Shock Proteins, Hsp26, Hsp70, Hsp90, and Hsp104, on Expanded Polyglutamine Fragments Revealed by Chemical Probes. J Biol Chem. 2011; 286(47): 40486–40493.