J9

Glucocorticoid resistance inhibitor

Catalog No. SIH-182

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CAS No.
Molecular Formula C12H12N4
SKU: SIH-182 Categories: ,

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SIH-182_J9_Chemical_Structure.png
Product Name J9
Description

Glucocorticoid resistance inhibitor

Purity 99.90%
Molecular Formula C12H12N4
Molecular Weight 212.26
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Product Type Inhibitor
Solubility Soluble in CDCI3
Source Synthetic
Appearance White Solid
SMILES NC1=NC(C2CC2)=C(C3=CC=NC=C3)C=N1
InChI InChI=1S/C12H12N4/c13-12-15-7-10(8-3-5-14-6-4-8)11(16-12)9-1-2-9/h3-7,9H,1-2H2,(H2,13,15,16)
InChIKey PQLYPFZAOUDDHB-UHFFFAOYSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product J9 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-182)

Biological Description

Alternative Names J9,4-cyclopropyl-5-(pyridin-4-yl)pyrimidin-2-amine
Research Areas Cancer, Cell Signaling
PubChem ID PMC4094258
Scientific Background J9, in combination with dexamethasone inhibits cell growth in T-cell acute lymphoblastic leukemia (T-ALL) through the upregulation of the glucocorticoid receptor. Patients can develop glucocorticoid resistance rendering the treatment ineffective. J9 and its mechanism of action provides a useful strategy for overcoming the resistance. The EC50 of J9 in combination with dexamethasone is 28 uM. J9 alone was less toxic.
References 1. Cantley A.M., et al. (2014) ACS Medicinal Chemistry Letters 5.7: 754-759.

Product Images

<p>Chemical structure of J9 (SIH-182), a Glucocorticoid resistance inhibitor. CAS #: . Molecular Formula: C12H12N4. Molecular Weight: 212.26 g/mol.</p>

Chemical structure of J9 (SIH-182), a Glucocorticoid resistance inhibitor. CAS #: . Molecular Formula: C12H12N4. Molecular Weight: 212.26 g/mol.

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