Alpha-synuclein is a recent discovery. The protein became apparent after identification as the main amyloid structure, which had a significant impact on Alzheimer’s disease. Further studies established that the protein also had a considerable role in Parkinson’s disease. Observation indicates that alpha-synuclein fills up inclusions in Levy bodies, known as intracytoplasmic spaces. These bodies contribute to the etiology of Parkinson’s illness.
Further scientific research reveals that this protein forms a bridge between Alzheimers and Parkinson’s with the dominant mutation of the cells. It is conclusive that the protein is the dominant underlying structure responsible for both illnesses. The dysfunction of the diseases could be investigated further by investigating the physiological function of the protein.
Expression of alpha-synuclein PFF
This protein has a predominant expression in the brain. Scientists observe its concentration in the presynaptic terminals of the nerve. It has a dominant presence in the mitochondria of the following structures:
Functions of alpha-synuclein
Properties of alpha-synuclein
Selecting the right species
The chosen protein can affect the rate of progression and level of pathology. This case is because it is essential to get the correct homology between the species and the host. PFFs are convenient for creating the right template, than alpha-synuclein monomers. Similarly, the monomers are better at certain aspects that other forms.
The importance of observing the interaction between the host and the PFF was evident after confirmation of the higher levels of staining in vitro cultures. This case was apparent after a study of incubation by a mouse aSyn PFFs.
Highlights of alpha-synuclein PFF
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