Tau protein is a protein-based microtubule. PHF Tau has an association with the functioning of the cytoskeletal network of structures.  Its dominant expression is in neurons and systems like E. Coli.

In-depth definition of tau protein

The name arises from the Greek letter ‘t.’ The primary purpose of this protein is the transportation of axoplasmic neurons. Hyperphosphorylated tau collects itself along with ubiquitin, in aging neurons. 

Tau is present in the cytoplasm of patients with a complete impairment of cognitive power. The complexes of ubiquitin have numerous and widespread in several structures of the brain, such as the following sections:

  • Frontal lobes
  • Hippocampus
  • Temporal cortex 

Mutations of the tau gene have an association with the gene present in chromosome 17. These mutations are present in familial cases of dementia. 

How tau damages brain cells

Scientific research has found the exact mechanism by which tau protein destroys the cells of the brain. The study explains that the proteins interfere with the regular communication of the cells’ neurons. 

Scientists from the general hospital of Massachusetts in Charlestown and John Hopkins in Baltimore set a project to establish how the protein contributes to damage of brain cells. They sought to understand the sixth most common cause of deaths in the USA – Alzheimer's disease.

The exact causes of the illness are unclear to science. Current studies indicate the main reasons to be changed in the following factors:

  • Genes
  • Lifestyle
  • Environment
  • Age – This factor causes shrinkage in parts of the brain, causing instability and short life of molecules; hence, the production of cellular energy undergoes constant disruption. 

The biological observation of Alzheimer’s indicates two main features:

  • Formation of plaques between cells
  • Tangles of tau protein in cells 

Communication between neural cells

The active components that carry elements from the cell connect it with other parts of the cell. Tau protein binds and stabilizes microtubules in a healthy brain, but will typically have different behavior in an Alzheimer patient. Changes in the brain make tau separate from the microtubules and stick together. The detached molecules create long filaments that interfere with the regular flow of signals between neurons.

The communication between the cellular structures occurs through the nuclear pores, which is dependent on the 400 available proteins. Studies suggest that the particular interference occurs in these specific nuclear pores. The observation of nuclear pores was also evident in patients who suffered from other types of dementia.

Recent studies show that Alzheimer’s disease has significant faults within the pores. The error has linkage to the tau accumulation in brain cells. The subsequent result of the interaction between the nuclear pore and tau is a complete change of the inherent properties. 

Tau targeted the structural formula of proteins with Nup98. Studies on Alzheimer’s show that there are few nuclear cells. Most of the present ones tended to get stuck close to one another. 

Stress Marq Biosciences has PHF tau with a purity rating of approximately ninety-five percent. The product is excellent for use in research because it has undergone the necessary purification processes.


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