Phospho Tau Antibody

Phospho Tau Antibody

The suggested host species of an experiment with phosphor tau antibody are non-human candidates, despite its high response rate with humans. Alternatives include a mouse, rat, or rabbit. The phospho tau antibody detects phosphorylated tau at serine 96. Tested applications indicate that it is available for the following cases:

  • IHC-P
  • Dot blot
  • WB
  • IHC-Fr

It is not suitable for applications on ICC/IF. The synthetic peptide corresponds to the human tau, aa350 of the C-terminus. 

What is the function of the phospho tau antibody from Stress Marq?

  • The antibody promotes the stability and assembly of the microtubule.
  • It has a role in the maintenance and establishment of the polarity of neurons
  • The C-terminus forms a bond with the axon microtubules, while the N-terminus binds to the membrane components of the neural plasma – The benefit is that tau works like a linker of both proteins

The axon property undergoes a predetermination phase by the localization of tau, which dominates the cell body. The shortness of the isoform gives way to the plasticity of the cytoskeleton, whereas isoforms play a role in the stabilization process.

Specification of the tissue

The antibody has its most dominant expression in neurons of the peripheral nervous system and the central nervous system. 

Participation of the illness

The neuron system of the cytoskeleton experiences continuous disruptions and replacement by entanglement with PHF and straight filaments, whose main characteristic is tau. The result is dementia, including common frontotemporal dementia. 

Frontotemporal dementia has a presenile that harms mental and behavior health. The changes include atrophy that has an association with the basal ganglia, amygdala, and substantia nigra. 

Defects of the MAPT cause Pick illness, which is a rare type of dementia. It has characteristics like:

  • Swollen neurons
  • Presence of tau
  • Presence of pick bodies
  • Confusion
  • Aphasia
  • Apraxia
  • Deformation of the persona
  • Other cases seem to have sporadic effects with a leading association of a regular haplotype. Family genotypes indicate an autosomal pattern with incomplete penetration and subsequent breaks neural signals. 

Background of tau protein

The pathological concentrates of tau are present in frontotemporal dementia and Alzheimer’s disease. Studies indicate that there is an apparent difference between the tau inflictions on the two conditions. The tau pathology in AD is different from that in FTD. It increases after a stroke and may have an impact on the physiological quotient of vascular dementia. 

Investigation of tau in CSF

The involvement of complete tau CSF and phosphorylated CSF is different in varying types of dementia. 

Conclusions

CSF and CSF tau phospho tau had a significant increase in probable AD. The CSF version was higher than the AD comparison with FTD. Its molecular weight forms range between 80kDa and 25kDa. Both versions have an FTD correlation in all groups. 

The phospho and non-phospho tau isoforms were present in CSF, and evident in the full length and truncated forms of tau proteins. CSF concentrations gain an increase in two-thirds of patients with a potential occurrence of AD, or with typical cases of PD, SAE, and FTD. The values of the normal range do no free AD.

 

 

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