Recombinant Tau

Recombinant Tau

While degenerative diseases continue to plague more and more people each passing year, scientists are determined to research treatments that can cure them. In order to accomplish this, the creation of proteins similar to those found in the central nervous system of the human body is necessary. At StressMarq Biosciences Inc., we manufacture recombinant Tau proteins that are essential in studying the biology of Alzheimer’s disease.

What are Tau Proteins?

These are neuronal proteins commonly found in human brain tissue. Their main function is to stabilize microtubules, which are fibrous shafts that provide support to the cellular structure. Tau proteins do this by binding to them.

There are six isoforms of the tau protein in the brain. The number of binding domains is what differentiates them. These domains are positively charged, which allows them to bind to the negatively charged microtubules.

Relationship Between Tau Proteins and Alzheimer’s Disease

Patients of Alzheimer’s disease have been found to have paired helical filaments, made up of tangled forms of Tau proteins. It has been established that hyperphosphorylation of normal proteins makes them dysfunctional, resulting in degenerative neurofibrils. Normally, phosphorylation of Tau occurs in about 30 sites.

The process involves the chemical addition of a phosphoryl group to the protein. That regulates most cellular processes, including growth. When there’s too much chemical addition, however, the organization of the microtubules is disrupted. Since the microtubules are also part of the transport system in neurons, neural pathways are destroyed, a situation that causes degenerative ailments.

What are Recombinant Tau Proteins?

Tau proteins identified as recombinant are those encoded by recombinant DNA. Recombinant DNA is a gene that has been formed through laboratory processes using genetic material from different organisms or sources. When the gene is modified, a mutant protein is formed.

Applications of Recombinant Tau Proteins

These proteins are commonly applied in the following fields:

  • Research – With the association of Tau proteins found in the brain and Alzheimer’s disease, there has been an increase in research using mutant Tau fibrils. In the laboratory, they are used to determine the role of different genes in cellular activities such as metabolism and cell signaling. Furthermore, they’re instrumental in locating proteins encoded by specific genes. By doing that, they provide more insight into the fundamental function of an organism. This has made these proteins useful in biochemistry, cell biology, molecular biology, biophysical studies, and many other biological research fields.
  • Medicine – The dysfunction of various proteins within the body is related to most diseases. DNA encoding enables the making of therapeutic proteins for ailments such as anemia, diabetes, and cancer. These proteins are made to replace the abnormal, hyperphosphorylated ones, hence regulating microtubule activity. Some are even used as vaccines to protect against autoimmune diseases and foreign agents.

Boost Your Research Project

The recombinant Tau proteins offered at StressMarq Biosciences Inc. are meant for research purposes. They are made to suit various applications, including WB, In Vitro assay, In Vivo assay, and SDS-PAGE. To get more information concerning our products, call us today on +1 250 294-9065.

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