While degenerative diseases continue to plague more and more people each passing year, scientists are determined to research treatments that can cure them. In order to accomplish this, the creation of proteins similar to those found in the central nervous system of the human body is necessary. At StressMarq Biosciences Inc., we manufacture recombinant Tau proteins that are essential in studying the biology of Alzheimer’s disease.
What are Tau Proteins?
These are neuronal proteins commonly found in human brain tissue. Their main function is to stabilize microtubules, which are fibrous shafts that provide support to the cellular structure. Tau proteins do this by binding to them.
There are six isoforms of the tau protein in the brain. The number of binding domains is what differentiates them. These domains are positively charged, which allows them to bind to the negatively charged microtubules.
Relationship Between Tau Proteins and Alzheimer’s Disease
Patients of Alzheimer’s disease have been found to have paired helical filaments, made up of tangled forms of Tau proteins. It has been established that hyperphosphorylation of normal proteins makes them dysfunctional, resulting in degenerative neurofibrils. Normally, phosphorylation of Tau occurs in about 30 sites.
The process involves the chemical addition of a phosphoryl group to the protein. That regulates most cellular processes, including growth. When there’s too much chemical addition, however, the organization of the microtubules is disrupted. Since the microtubules are also part of the transport system in neurons, neural pathways are destroyed, a situation that causes degenerative ailments.
What are Recombinant Tau Proteins?
Tau proteins identified as recombinant are those encoded by recombinant DNA. Recombinant DNA is a gene that has been formed through laboratory processes using genetic material from different organisms or sources. When the gene is modified, a mutant protein is formed.
Applications of Recombinant Tau Proteins
These proteins are commonly applied in the following fields:
Boost Your Research Project
The recombinant Tau proteins offered at StressMarq Biosciences Inc. are meant for research purposes. They are made to suit various applications, including WB, In Vitro assay, In Vivo assay, and SDS-PAGE. To get more information concerning our products, call us today on +1 250 294-9065.