MG-132

Name: MG-132
SKU: SIH-326
Availability: InStock

Proteasome Inhibitor

Catalog No. SIH-326

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CAS No.	133407-82-6
Molecular Formula	C26H41N3O5

SKU: SIH-326 Categories: Inhibitor, Small Molecules

Product Name	MG-132
Description	Proteasome Inhibitor
Purity	>98%
CAS No.	133407-82-6
Molecular Formula	C₂₆H₄₁N₃O₅
Molecular Weight	475.6
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in 45 mg/ml DMSO, DMF and ethanol
Source	Synthetic
Appearance	White solid
SMILES	CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
InChI	InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0
InChIKey	TZYWCYJVHRLUCT-VABKMULXSA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
Cite This Product	MG-132 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-326)

Alternative Names	N-[(Benzyloxy)carbonyl]-L-leucyl-N-[(2S)-4-methyl-1-oxo-2-pentanyl]-L-leucinamide, Z-Leu-Leu-Leu-al, Z-LLL-CHO, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide
Research Areas	Cancer, Heat Shock
PubChem ID	462382
Scientific Background	Specific inhibitor of the 20S proteasome (Ki=4 nM). Blocks NFKB activation by blocking IKB proteolysis (IC50=3 M). It stimulates autophagy, induces heat shock response and is cell permeable
References	1. Tsubuki S., et al. (1996) J. Biochem. 119:572. 2. Wu W.K., et al. (2010) Autophagy 6:228. 3. Meriin A.B., et al. (1998) J. Biol. Chem. 273:6373.

Chemical structure of MG-132 (SIH-326), a Proteasome Inhibitor. CAS #: 133407-82-6. Molecular Formula: C26H41N3O6. Molecular Weight: 476.6 g/mol.

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