Products

  • Alpha Synuclein Filaments (Discontinued)

    Human Recombinant Alpha Synuclein Filaments

    Catalog No. SPR-450

    0 out of 5 based on 0 customer ratings
    Reviews (0)
    Expression System E. coli
    Tags No tag
    SKU: SPR-450 Category:

    Bulk Quote
    SPR-450_Alpha-Synuclein-Protein-Filaments-Protein-TEM-2.png
    TEM of Active Human Recombinant Alpha Synuclein Protein Filaments (SPR-450)

  • GRP78 (Bip) Protein

    Human Recombinant GRP78 (Bip) Protein

    Catalog No. SPR-107

    5.00 out of 5 based on 1 customer rating
    Reviews (1)
    Expression System E. coli
    Tags His tag
    SKU: SPR-107 Category:

    Bulk Quote
    SPR-107_GRP78_Protein_SDS-Page.png

  • Alpha Synuclein Monomers

    Human Recombinant Alpha Synuclein Monomers (Type 2)

    Catalog No. SPR-316

    0 out of 5 based on 0 customer ratings
    Reviews (0)
    Expression System E. coli
    Tags No tag
    SKU: SPR-316 Category:

    Bulk Quote
    SPR-316_Alpha-Synuclein-Protein-Monomer-Protein-SDS-Page-1.png
    Alpha Synuclein monomers (SPR-316) do not form new alpha synuclein fibrils when combined with Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by a limited increase in fluorescence intensity by Thioflavin T over time.Alpha Synuclein Monomer RT-QuiC AssayΑlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.LDH assay shows effect of alpha synuclein monomers on mouse primary neuronsMTT assay shows effects of alpha synuclein monomers on mouse primary neurons

  • Alpha Synuclein E114C Mutant Pre-formed Fibrils: ATTO 488

    Human Recombinant Alpha Synuclein E114C Mutant PFFs: ATTO 488

    Catalog No. SPR-518-A488

    0 out of 5 based on 0 customer ratings
    Reviews (0)
    Expression System E. coli
    Tags ATTO 488
    SKU: SPR-518-A488 Category:

    This product is currently out of stock and unavailable. Notify me when this product is available.

    SPR-518-A488_Alpha-Synuclein-E114C-Mutant-Pre-formed-Fibrils-ATTO-488-Protein-ICC-IF-neuronal-uptake-1.png
    Representative TEM image of ATTO-488 conjugated Alpha Synuclein E114C Pre-Formed Fibrils (SPR-518-A88)Representative TEM image of ATTO-488 conjugated Alpha Synuclein E114C Pre-Formed Fibrils (SPR-518-A88)Fluorescent signal of alpha-synuclein E114C-ATTO-488 PFFs (SPR-518-A88)In vitro seeding activity of human Alpha Synuclein wildtype monomer in ThT assay. (SPR-518-A88)Sedimentation assay on ATTO-488 conjugated Alpha Synuclein E114C Pre-Formed Fibrils. (SPR-518-A88)SDS-PAGE analysis of ATTO-488 conjugated Alpha Synuclein E114C Pre-Formed Fibrils (SPR-518-A88)

  • Alpha Synuclein Pre-formed Fibrils

    Human Recombinant Alpha Synuclein PFFs (Type 2)

    Catalog No. SPR-317

    5.00 out of 5 based on 2 customer ratings
    Reviews (2)
    Expression System E. coli
    Tags No tag
    SKU: SPR-317 Category:

    Bulk Quote
    SPR-317_Alpha-Synuclein-Preformed-Fibrils-Protein-TEM-4.png
    TEM of Type 2 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-317)Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.SDS-Page of Type 2 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-317)Type 2 alpha synuclein Pre-formed fibrils (SPR-317) do not seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) at the same rate as Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by lower fluorescence intensity values of Thioflavin T over time.Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).Toxicity results comparing Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2) and Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)LDH assay shows effect of alpha synuclein PFFs on mouse primary neuronsMTT assay effects of alpha synuclein PFFs on mouse primary neurons

  • Alpha Synuclein Pre-formed Fibrils: ATTO 594

    Human Recombinant Alpha Synuclein PFFs: ATTO 594 (Type 1)

    Catalog No. SPR-322-A594

    5.00 out of 5 based on 1 customer rating
    Reviews (1)
    Expression System E. coli
    Tags ATTO 594
    SKU: SPR-322-A594 Category:

    Bulk Quote
    SPR-322-A594_Alpha-Synuclein-Protein-Protein-TEM-1.png
    Thioflavin T Assay for SPR-322-A594Human iPSC-derived neurons seeded with ATTO594 labelled alpha synuclein PFFs (SPR-322-A594)TEM of ATTO conjugated alpha syuclein pre-formed fibrils

  • Tau (K18) P301L Mutant Pre-formed Fibrils

    Human Recombinant Tau (K18) P301L Mutant Pre-Formed Fibrils (fibrillized without heparin)

    Catalog No. SPR-523

    0 out of 5 based on 0 customer ratings
    Reviews (0)
    Expression System E. coli
    Tags No tag
    SKU: SPR-523 Category:

    Bulk Quote
    SPR-523_Tau-K18-P301L-Mutant-Pre-formed-Fibrils-Protein-SDS-Page-1.png
    TEM of Tau (K18) P301L Mutant Pre-formed Fibrils (SPR-523)Native-PAGE of Tau (K18) P301L Mutant Pre-formed Fibrils (SPR-523)Thioflavin T assay of Tau (K18) P301L Mutant Pre-formed Fibrils (SPR-523)TEM of Tau (K18) P301L Mutant Pre-formed Fibrils (SPR-523)AFM of Tau (K18) P301L Mutant Pre-formed Fibrils (SPR-523)Toxicity of Tau (K18) P301L Mutant Pre-formed Fibrils (SPR-523)

  • TDP-43 Hexamutant (W→S) Monomers

    Human Recombinant TDP-43 (W68S, W113S, W172S, W334S, W385S, W412S) Mutant Monomers

    Catalog No. SPR-522

    0 out of 5 based on 0 customer ratings
    Reviews (0)
    Expression System E. coli
    Tags No tag
    SKU: SPR-522 Category:

    Bulk Quote
    SPR-522_TDP-43-Hexamutant-W→S-Monomers-Protein-SDS-Page-1.png

  • Tau dGAE (297-391) AD-mimic Pre-formed Fibrils

    Human Recombinant Tau dGAE (297-391) AD-mimic PFFs (fibrillized without heparin)

    Catalog No. SPR-502

    0 out of 5 based on 0 customer ratings
    Reviews (0)
    Expression System E. coli
    Tags No tag
    SKU: SPR-502 Category:

    Bulk Quote
    SPR-502_Tau-dGAE-297-391-AD-mimic-Pre-formed-Fibrils-Protein-TEM-1.png
    SDS-Page of Human Tau dGAE (297-391) AD-mimic Pre-formed Fibrils Protein (SPR-502)TEM of Human Tau dGAE (297-391) AD-mimic Pre-formed Fibrils Protein (SPR-502)TEM of Human Tau dGAE (297-391) AD-mimic Pre-formed Fibrils Protein (SPR-502)

  • Tau-441 (2N4R) Wild-Type Oligomers

    Human Recombinant Tau-441 (2N4R) Wild-Type Oligomers (Baculovirus/Sf9)

    Catalog No. SPR-497

    0 out of 5 based on 0 customer ratings
    Reviews (0)
    Expression System Baculovirus (Sf9)
    Tags No tag
    SKU: SPR-497 Category:

    Bulk Quote
    SPR-497_Tau-441-2N4R-Wild-Type-Oligomers-Protein-AFM-1.png
    Native-PAGE of Tau-441 (2N4R) Wild-Type Oligomers (SPR-497)Toxicity of Tau-441 (2N4R) Wild-Type Oligomers (SPR-497)SDS-Page of Tau-441 (2N4R) Wild-Type Oligomers (SPR-497)Dot Blot of Tau-441 (2N4R) Wild-Type Oligomers (SPR-497)