DAPT

Name: DAPT
SKU: SIH-378
Availability: InStock

γ-secretase inhibitor

Catalog No. SIH-378

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CAS No.	208255-80-5
Molecular Formula	C23H26F2N2O4

SKU: SIH-378 Categories: Inhibitor, Small Molecules

Product Name	DAPT
Description	γ-secretase inhibitor
Purity	>99%
CAS No.	208255-80-5
Molecular Formula	C₂₃H₂₆F₂N₂O₄
Molecular Weight	432.46
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble to 100 mM in DMSO
Source	Synthetic
Appearance	White to off-white powder
SMILES	[C@H](NC(=O)[C@@H](NC(=O)CC1=CC(=CC(=C1)F)F)C)(C2=CC=CC=C2)C(OC(C)(C)C)=O
InChI	InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
InChIKey	DWJXYEABWRJFSP-XOBRGWDASA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product	DAPT (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-378)

Alternative Names	N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester
Research Areas	Cell Signaling, Neuroscience
PubChem ID	5311272
Scientific Background	Inhibitor of γ-secretase; causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. Does not affect APPα and APPβ levels. Blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation.
References	1. Dovey H.F., et al. (2001) J. Neurochem. 76(1): 173-81. 2. De Smedt M., et al. (2005) Blood. 106(10): 3498-506. 3. Kanungo J., et al. (2008) J. Neurochem. 106(5): 2236-48.

Chemical structure of DAPT (SIH-378), a γ-secretase inhibitor. CAS #: 208255-80-5. Molecular Formula: C23H26F2N2O4. Molecular Weight: 432.46 g/mol.

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