Antibodies - Heat Shock Proteins, Oxydative Stress, Apoptosis, Cell Signaling

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Product Name: UT-A1
Catalog #: SPC-406D
Alternative Names: Slc14a2
Clone Number: N/A
Immunogen: Produced against a synthetic peptide mappint to the C-terminal tail of rat UT-A1, amino acids 911-929 (antibody designation L194).
Accession Number: NP_062220
Gene ID: 54302
SwissProt: Q62668
Applications: WB, ICC
Host Species: Rabbit
Isotype: N/A
Species Reactivity: Rat, Mouse
Recommended Dilutions: 1:1000 (WB)
Form: Affinity Purified
Storage Buffer: Rabbit immunoglobulin in 50% glycerol
Concentration: N/A
Background Info: Detects ~97 and 127kDa.
Conjugate: N/A
Package Size: 100ul
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C
Datasheet: SPC 406 UT A1 (Slc14a2) Ion Channel
Research Area: Transporters
Certificate of Analysis: 1 μg/mL of SPC-406 was sufficient for detection of UT-A1 in 20μg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Price: $295.00 USD Add to Cart Bulk Quote

Western blot analysis of UT-A1 in rat inner medulla using a 1:1000 dilution of SPC-406.

Research Background: UT-A1, a kidney-specific urea transporter is expressed in the renal collecting duct where it mediates trans-epithelial urea transport and is a target for regulation by vasopressin. Urea movement out of the collecting duct in the inner medulla of the kidney allows accumulation of urea in the medullary interstitium, thereby allowing maximum water reabsorption from the collecting ducts. (The antibody also recognizes a second protein from the UT-A gene driven by transcription from an alternative promotor and expressed in the thin descending limb of Henle, viz. UT-A2.) (1, 2)
References: 1. Nielsen S, Terris J, Smith CP, Hediger MA, Ecelbarger CA, Knepper MA. (1996) Proc Natl Acad Sci U S A. 93(11): 5495-500.
2. Smith C.P. (2009) Exp Physiol. 94(2): 180-185.

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