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Product Name: 17-AAG
Catalog #: SIH-100A
Size: 1mg
Type: Inhibitor
Description: Hsp90 inhibitor
Research Area: Heat Shock
CAS Number: 75747-14-7
Formula: C31H43N3O8
Molecular weight: 585.7
Source/Host: Synthetic
Purity: 98% TLC:5% methanol/methylene chloride; Rf=0.26
Solubility: Soluble in DMSO (›20mg/mL) or methanol (10mg/mL)
Appearance: Purple Solid
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C
Safety Phrases: Classification: Caution: Substance not yet fully tested.

Safety Phrases: S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Datasheet: SIH 100 17 AAG Heat Shock Inhibitor
Price: $175.00 USD Add to Cart

Structure of 17-AAG

Research Background: Glendanamycin (GA), a benzoquinone ansamycin antibiotic, interferes with the action of Hsp90 leading to degradation of Hsp90 client proteins. GA itself however has undesirable properties such as poor aqueous solubility and liver toxicity; therefore, numerous analogs have been synthesized, such as 17-AAG(1). 17-AAG is an HSP-90 inhibitor that displays a 100-fold higher affinity for HSP-90 derived from tumor cells compared to HSP-90 from normal cells(2). 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol(3), cisplatin(4) and UCN-01 (400 nM 17-AAG, U937 cells)(5).
References: 1. Neckers L. (2002) Trends Mol Med. 84: S55-61.
2. Kamal A., et al.(2003) Nature 425: 407.
3. Solit D.B., et al.(2003) Cancer Res. 63: 2139.
4. Vasilevskaya I.A., et al. (2003) Mol.Pharmacol. 2003 65: 235.
5. Jia W., et al.(2003) Blood 102: 1824.

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