Small Molecules - Apoptosis, Cellular Oxidative Stress,

Home > Products > Small Molecules > SIH-112A

Product Name: Geldanamycin-Biotin
Catalog #: SIH-112A
Size: 1mg
Type: Inhibitor
Description: Hsp90 inhibitor
Research Area: Heat Shock
CAS Number: 30562-34-6
Formula: C55H87N7O17S
Molecular weight: 560.6
Source/Host: Synthetic
Purity: 98%
Solubility: Soluble in DMSO
Appearance: Purple Solid
Storage Temp: 4°C
Shipping Temp: Blue Ice or 4°C
Safety Phrases: Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.

Safety Phrases: S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Risk Phrases: R68- Possible risk of irreversible effects
Datasheet: SIH 112 Geldanamycin Biotin Heat Shock Inhibitor
Price: $180.00 USD Add to Cart

Structure of Geldanamycin: Biotin

Research Background: Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1, 2). It induces the inactivation, destabilization and eventual degradation of HIF-1α (3). This inhibitor is a useful tool for affinity purification of HSP-90 and HSP-90 dependent client proteins (4).
References: 1. Whitesell L., et al. (1994) Proc. Natl Acad. Sci. USA 91:8324.
2. Neckers L. (2002) Trends Mol. Med. 8: S55.
3. Mabjeesh N.J., et al. (2002) Cancer Res. 62: 2478.
4. Clevenger R.C. et al. (2004) J. Org. Chem. 69: 4375.

Full Name:	*
Company:	*
Phone:	*
Email:	*
Address:	*
Address 2:
City:	*
State/Province:
Country:	*
Zip/Postal:	*
Primary Work Interest:	*
Newsletter Sign-Up:	* Yes No
Check box before sending form:	*