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Product Name: 17-DMAG
Catalog #: SIH-114A
Size: 1mg
Type: Inhibitor
Description: Hsp90 inhibitor
Research Area: Heat Shock
CAS Number: 30562-34-6
Formula: C32H48N4O8
Molecular weight: 616.8
Source/Host: Synthetic
Purity: 98% (TLC: 10% Methanol/methylene chloride; Rf=0.49)
Solubility: Soluble in DMSO (›25mg/mL and ethanol (10mg/mL)
Appearance: Purple Solid
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C
Safety Phrases: Classification: Caution: Substance not yet fully tested.

Safety Phrases: S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Datasheet: SIH 114 17 DMAG Heat Shock Inhibitor
Price: $175.00 USD Add to Cart

Structure of 17-DMAG

Research Background: 17-DMAG is a water soluble & cell-permeable analog of Geldanamycin and 17-AAG (1). It binds to the APTase site of human Hsp90a with high affinity, has cytotoxic activity against many cancer cell lines (2), and acts as angiogenesis inhibitor (3). This Hsp90 inhibitor shows promise in preclinical models. 17-DMAG has excellent bioavailability, is widely distributed to tissues, and is quantitatively metabolized much less than is 17-AAG.
References: 1. Bull E.E., et al.(2004) Clin. Cancer Res. 10: 8077.
2. Gossett D.R. et al.(2005) Gynecol. Oncol. 96: 381.
3. Kaur G. et al.(2004) Clin. Cancer Res. 10: 4813.

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