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| Product Name | Sphingosine |
| Description |
Protein Kinase C inhibitor |
| Purity | >98% |
| CAS No. | 123-78-4 |
| Molecular Formula | C18H37NO2 |
| Molecular Weight | 299.49 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO |
| Source | Synthetic |
| Appearance | Solid |
| SMILES | CCCCCCCCCCCCC/C=C/[C@H]([C@H](CO)N)O |
| InChI | InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1 |
| InChIKey | WWUZIQQURGPMPG-KRWOKUGFSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Sphingosine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-202) |
Biological Description
| Alternative Names | (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors |
| PubChem ID | 5280335 |
| Scientific Background | Sphingosine can be phosphorylated in vivo via two kinases which leads to the formation of a potent signaling lipid. It is a selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. It also inhibits calmodulin-dependent enzymes and is the precursor of ceramide. |
| References |
1. Radin N. (2003) Biochem J. 371(Pt2): 243-256. 2. Carter H.E., Glick F.J., Norris W.P., Phillips G.E. (1947) J Biol Chem. 170: 285-295. |
Product Images
Chemical structure of Sphingosine (SIH-202), a Protein Kinase C inhibitor. CAS #: 123-78-4. Molecular Formula: C18H37NO2. Molecular Weight: 299.49 g/mol.
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Based on validation through cited publications.