Small Molecules - Apoptosis, Cellular Oxidative Stress,

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Product Name: Rapamycin
Catalog #: SIH-212-25MG
Size: 25mg
Type: Inhibitor
Description: mTOR inhibitor
Research Area: Apoptosis
CAS Number: 53123-88-9
Formula: C51H79NO13
Molecular weight: 914.18
Source/Host: Synthetic
Purity: >99%
Solubility: Soluble to 100mM in ethanol, and to 50mM in DMSO.
Appearance: White Solid
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C
Safety Phrases: Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.

Safety Phrases: S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Risk Phrases: R68- Possible risk of irreversible effect
Datasheet: SIH 212 Rapamycin Apoptosis Inhibitor
Price: $299.00 USD Add to Cart Bulk Quote

Structure of Rapamycin

Research Background: Rapamycin or Sirolimus is an immunosuppressant and antifungal. It inhibits the response to interleukin-2, and therefore blocks activation of T and B cells. It binds FKBP12 which then inhibits the mTOR pathway (1). There is also potential treatment for Alzheimer;s, autism and HIV infection (2-3)
References: 1. Gruppuso P.A., Boylan J.M., and Sanders J.A. (2011) Cell Cycle. 10(7): EPub.
2. Ehninger D., et al. (2008) Nat. Med. 14(8): 843-848.
3. Donia M., McCubrey J.A., Bendtzen K., and Nicoletti F. (2010) Br J Clin Pharmacol. 70(6): 784-793.

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