Small Molecules - Apoptosis, Cellular Oxidative Stress,

Home > Products > Small Molecules > SIH-214-50MG

Product Name: FK506
Catalog #: SIH-214-50MG
Alternative Names: Tacrolimus, Fujimycin
Size: 50mg
Type: Inhibitor
Description: FKBP inhibitor
Research Area: Apoptosis
CAS Number: 109581-93-3
Formula: C44H69NO12
Molecular weight: 804.02
Source/Host: Synthetic
Purity: >99%
Solubility: Soluble to 100mM in ethanol, and to 100mM in DMSO.
Appearance: White Solid
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C
Safety Phrases: Classification: Caution: Substance not yet fully tested.

Safety Phrases: S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Hazard Phrases: H301

Precautionary Phrases: P301 + P310
Datasheet: SIH 214 FK506 Apoptosis Inhibitor
Price: $425.00 USD Add to Cart Bulk Quote

Structure of FK-506

Research Background: FK506 or Fujimycin or Tacrolimus, is an immunosuppressant. It is mainly used after allogeneic organ transplants, but can also be used topically in the treatment of eczema, uveitis and vitiligo (1). It is a macrolide that prevents the dephosphorylation of NF-AT. It reduces peptidyl-prolyl isomerase activity by binding to FKBP12 creating a new complex that interacts with and inhibits calcineurin (2, 3).
References: 1. Nanette B., et al. (2004) J Am Acad Derm. 51(5): 760-766.
2. Ganong W.F., Review of Medical Physiology (22nd ed.) Lange Medical Books. P.530
3. Liu J. Lane W., Friedman J, Weissman I and Schreiber S. (1991) Cell. 66(4): 807-816

Full Name:	*
Company:	*
Phone:	*
Email:	*
Address:	*
Address 2:
City:	*
State/Province:
Country:	*
Zip/Postal:	*
Primary Work Interest:	*
Newsletter Sign-Up:	* Yes No
Check box before sending form:	*