Small Molecules - Apoptosis, Cellular Oxidative Stress,

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Product Name: Myriocin (ISP-1)
Catalog #: SIH-233-25MG
Size: 25mg
Type: Inducer
Description: Blocks sphingolipid biosynthesis
Research Area: Apoptosis
CAS Number: 35891-70-4
Formula: C21H39NO6
Molecular weight: 401.54
Source/Host: Synthetic
Purity: >99%
Solubility: Soluble in 2mg/mL of methanol, DMSO (25mg/ml;heat briefly in boiling waterbath) or in dilute base(5mg/ml; 50mM NaOH)
Appearance: Off-white solid
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C
Safety Phrases: Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.

Safety Phrases: S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)

Risk Phrases: 22- Harmful if swallowed

Hazard Phrases: H301

Precautionary Phrases: P301 + P310
Datasheet: SIH 233 Myriocin (ISP 1) Apoptosis Inducer
Price: $174.00 USD Add to Cart Bulk Quote

Structure of Myriocin (ISP-1)

Research Background: Myriocin, or ISP-1, is an atypical amino acid and an antibiotic. It is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis (1). It was shown to inhibit the proliferation of an IL-2-dependent mouse cytotoxic T cell line. It also possesses immunosuppressant activity (2).
References: 1. Hidari K.I.P.J., et al. (1996) J Biol Chem. 271: 14636-14641.
2. Miyake Y., Kozutsumi Y., Nakamura S., Fujita T. and Kawasaki T. (1995) Biochem Piophys Res Commun. 211(2): 396-403.

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