Discovery through Partnership | Excellence through Quality
| Product Name | Myriocin (ISP-1) |
| Description |
Palmitoyltransferase inhibitor |
| Purity | >98% |
| CAS No. | 35891-70-4 |
| Molecular Formula | C21H39NO6 |
| Molecular Weight | 401.54 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 2 mg/ml of methanol, DMSO (25 mg/ml; heat briefly in boiling water bath) or in dilute base (5 mg/ml; 50 mM NaOH) |
| Source | Synthetic |
| Appearance | Off-White Solid |
| SMILES | CCCCCCC(=O)CCCCCC/C=C/C[C@H]([C@@H]([C@@](CO)(C(=O)O)N)O)O |
| InChI | InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1 |
| InChIKey | ZZIKIHCNFWXKDY-GNTQXERDSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label wherepossible) Risk Phrases: R22- Harmful if swallowed Hazard Phrases: H301 Precautionary Phrases: P301 + P310 |
| Cite This Product | Myriocin (ISP-1) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-233) |
Biological Description
| Alternative Names | (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-icosenoic acid |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 6438394 |
| Scientific Background | Myriocin, or ISP-1, is an atypical amino acid and an antibiotic. It is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis (1). It was shown to inhibit the proliferation of an IL-2-dependent mouse cytotoxic T cell line. It also possesses immunosuppressant activity (2). |
| References |
1. Hidari K.I.P.J., et al. (1996) J Biol Chem. 271: 14636-14641. 2. Miyake Y., Kozutsumi Y., Nakamura S., Fujita T. and Kawasaki T. (1995) Biochem Piophys Res Commun. 211(2): 396-403. |
Product Images
Chemical structure of Myriocin (ISP-1) (SIH-233), a Blocks sphingolipid biosynthesis. CAS #: 35891-70-4. Molecular Formula: C21H39NO6. Molecular Weight: 401.54 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.