Small Molecules - Apoptosis, Cellular Oxidative Stress,

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Product Name: Camptothecin
Catalog #: SIH-242-1G
Size: 1g
Type: Inducer
Description: Topoisomerase I inhibitor
Research Area: Apoptosis
CAS Number: 7689-03-4
Formula: C20H16N2O4
Molecular weight: 348.36
Source/Host: Synthetic
Purity: >99%
Solubility: Soluble to 5mM in DMSO.
Appearance: Yellow solid
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C
Safety Phrases: Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.

Safety Phrases: S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)

Risk Phrases: R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R46 - May cause heritable genetic damage

Hazard Phrases: H302
Datasheet: SIH 242 Camptothecin Apoptosis Inducer
Price: $315.00 USD Add to Cart Bulk Quote

Structure of Camptothecin

Research Background: Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I. It binds to the topo I and DNA complex, resulting in a tertiary comlex which stabilizes it. This prevents re-ligation and therefore causes DNA damage which results in apoptosis (1-3). It has showed remarkable anti-cancer activity in clinical trials.
References: 1. Adams D.J., et al. (2005) Cancer Chem and Pharm. 57(2): 145-154.
2. Redinbo M.R., Stewart L., Kuhn P., Champoux J.J. and Hol W.G.J. (1998) Science. 279:1504-1513.
3. Pommier Y., et al. (2003) Mutat Res. 532: 173-203.

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