Hypericin

Protein kinase C inhibitor

Catalog No. SIH-250

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CAS No. 548-04-9
Molecular Formula C30H16O8
SKU: SIH-250 Categories: ,

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SIH-250_Hypericin_Chemical_Structure.png
Product Name Hypericin
Description

Protein kinase C inhibitor

Purity >98%
CAS No. 548-04-9
Molecular Formula C30H16O8
Molecular Weight 504.45
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 10 mM in ethanol and to 50 mM in DMSO
Source Synthetic
Appearance Dark Red Solid
SMILES CC1=CC(=C2C3=C4C5=C(C(=CC(=C5C2=O)O)O)C6=C7C4=C8C(=C13)C(=CC(=C8C(=O)C7=C(C=C6O)O)O)C)O
InChI InChI=1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)2
InChIKey BTXNYTINYBABQR-UHFFFAOYSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product Hypericin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-250)

Biological Description

Alternative Names 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
PubChem ID 5281051
Scientific Background Hypericin is a naphtodianthrone that acts as an antibiotic and non-specific kinase inhibitor. It inhibits the action of dopamine beta-hydroxylase, leading to increased dopamine levels. Hypericin can also cause photosensitivity when ingested beyond threshold. And becase it also accumulates in cancerous tissues, it can be used as an indicator of cancerous cells (1, 2).
References 1. Hopfner M., et al. (2003) Int J Colorectal Dis. 18(3): 239-247.
2. Agostinis, et al. (2002) Int J Biochem Cell Biol. 34: 221.

Product Images

<p>Chemical structure of Hypericin (SIH-250), a Protein kinase C inhibitor. CAS #: 548-04-9. Molecular Formula: C30H16O8 . Molecular Weight: 504.45 g/mol.</p>

Chemical structure of Hypericin (SIH-250), a Protein kinase C inhibitor. CAS #: 548-04-9. Molecular Formula: C30H16O8 . Molecular Weight: 504.45 g/mol.

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