Staurosporine

Protein kinase inhibitor

Catalog No. SIH-253

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CAS No. 62996-74-1
Molecular Formula C28H26N4O3
SKU: SIH-253 Categories: ,

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SIH-253_Staurosporine_Chemical_Structure.png
Product Name Staurosporine
Description

Protein kinase inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 62996-74-1
Molecular Formula C28H26N4O3
Molecular Weight 466.54
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 50 mM in DMSO
Source Synthetic
Appearance Pale Yellow Solid
SMILES C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(2
InChIKey HKSZLNNOFSGOKW-FYTWVXJKSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H340- H350
Precautionary Phrases:
P201-P308 + P313
Cite This Product Staurosporine (StressMarq Biosciences, Canada, Cat # SIH-253)

Biological Description

Alternative Names (2S,3R,4R,6R)-3-Methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
PubChem ID 44259
Scientific Background Staurosporine is a broad spectrum protein kinase inhibitor with activities ranging from anti-fungal to anti-hypertensive (1). Staurosporine is a typical ATP-competitive kinase inhibitor that binds to many kinases with high affinity, but with little selectivity (2).
References 1. Ruegg U.T., and Burgess G.M. (1989) Trends in Pharm Science. 10(6): 218-220.
2. Karaman M.W., et al. (2008) Nat. Biotechnol. 26(1): 127-132.

Product Images

<p>Chemical structure of Staurosporine (SIH-253), a Protein kinase inhibitor. CAS #: 62996-74-1. Molecular Formula: C28H26N4O3. Molecular Weight: 466.54 g/mol.</p>

Chemical structure of Staurosporine (SIH-253), a Protein kinase inhibitor. CAS #: 62996-74-1. Molecular Formula: C28H26N4O3. Molecular Weight: 466.54 g/mol.

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