Small Molecules - Apoptosis, Cellular Oxidative Stress,

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Product Name: Trichostatin A
Catalog #: SIH-254-5MG
Size: 5mg
Type: Inducer
Description: Histone deacetylase inhibitor
Research Area: Apoptosis
CAS Number: 58880-19-6
Formula: C17H22N2O3
Molecular weight: 302.37
Source/Host: Synthetic
Purity: >99%
Solubility: Soluble to 10mM in ethanol and to 50mM in DMSO
Appearance: Beige Solid
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C
Safety Phrases: Classification: Caution: Substance not yet fully tested.

Safety Phrases: S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Risk Phrases: R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed
R68 - Possible risk of irreversible effects

Hazard Phrases: H302-H312-H315-H317-H319-H332-H335

Precautionary Phrases: P261-P280-P305 + P351 + P338
Datasheet: SIH 254 Trichostatin A Apoptosis Inducer
Price: $476.00 USD Add to Cart Bulk Quote

Structure of Trichostatin A

Research Background: Trichostatin A is an antifungal and selectively inhibits the class I and II mammalian histon deacetlyase families of enzymes (1). TSA inhibits the eukayotic cell cycle during the beginning of the growth stage. It can be used to alter gene expression but interfering with the removal of acetyl groups thereby altering the ability of DNA transcription factors to access the DNA inside chromatin (2). It also has anti-cancer properties (3)
References: 1. Vanhaecke T., Papeleu P., Elaut G., Rogiers V. (2004) Curr Med Chem. 11(12): 1629-1643.
2. Yoshida, et al. (1990) J Biol Chem. 165: 17174.
3. Drummond D.C., et al. (2005) Annu Rev Pharmacol Toxicol. 45: 495-528.

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