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| Product Name | Sulindac Sulfide |
| Description |
COX inhibitor |
| Purity | >98% |
| CAS No. | 32004-67-4 |
| Molecular Formula | C20H17FO2S |
| Molecular Weight | 340.41 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 25 mM in DMSO, 3 mM in ethanol |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | CC1=C(C2=C(/C1=CC3=CC=C(C=C3)SC)C=CC(=C2)F)CC(=O)O |
| InChI | InChI=1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17- |
| InChIKey | LFWHFZJPXXOYNR-RQZCQDPDSA-N |
| Safety Phrases |
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed R62 - Possible risk of impaired fertility Hazard Phrases: H302-H317-H334-H361 Precautionary Phrases: P261-P280-P342 + P311 |
| Cite This Product | Sulindac Sulfide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-261) |
Biological Description
| Alternative Names | {(1Z)-5-Fluoro-2-methyl-1-[4-(methylsulfanyl)benzylidene]-1H-inden-3-yl}acetic acid |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 1548887 |
| Scientific Background | Sulindac is a nonsteroidal anti-inflammatory drug that is known to prevent recurrence and reduce colorectal polyps. It is a prodrug that is metabolized to a sulfide and sulfone derivative in vivo. The mechanism of action of both is the selective induction of apoptosis. The anti-inflammatory properties of sulindac are mediated by COX inhibition (1, 2). |
| References |
1. Frahm S., et al. (2004) Cancer Cell Int. 4:4. 2. Piazza G.A., et al. (1997) Cancer Res. 57(12): 2452-2459. |
Product Images
Chemical structure of Sulindac Sulfide (SIH-261), a NFkB inhibitor. CAS #: 32004-67-4. Molecular Formula: C20H17FO2S . Molecular Weight: 340.41 g/mol.
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