Small Molecules - Apoptosis, Cellular Oxidative Stress,

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Product Name: 2-APB
Catalog #: SIH-316-250MG
Alternative Names: 2-Aminoethoxydiphenylborane
Size: 250mg
Type: Inhibitor
Description: TRP blocker
Research Area: Ion Channels
CAS Number: 524-95-8
Formula: C14H16BNO
Molecular weight: 225.1
Source/Host: Synthetic
Purity: >99%
Solubility: Soluble to 100mM in DMSO and to 10mM in ethanol
Appearance: White solid
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C
Safety Phrases: Classification: Caution: Substance not yet fully tested.

Safety Phrases: S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Hazard Phrases: H302-H315-H317-H318-H335

Precautionary Phrases: P261-P280-P305 + P351 + P338
Datasheet: SIH 316 2 APB Ion Channel Inhibitor
Price: $79.00 USD Add to Cart Bulk Quote

Structure of AP-18

Research Background: 2-APB is a chemical that acts to inhibit IP3 receptors (1) and TRP channels (2). It is used to manipulate intracellular release of calcium ions and modify TRP channel activity. There is also evidence that 2-APB acts directly to inhibit gap junctions made of connexin26 or connexin32 (3).
References: 1. Diver J.M., Sage S.O., Rosado J.A. (2001) Cell Calcium. 30(5): 323-329
2. Xu S.Z., et al. (2005) Br J Pharamcol. 145(4): 320-328.
3. Tao L., and Harris A.L. (2007) Mol Pharmacol. 71(2): 570-579.

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