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Product Name: E-4031
Catalog #: SIH-317-50MG
Size: 50mg
Type: Inhibitor
Description: Herg channel blocker
Research Area: Ion Channels
CAS Number: 113559-13-0
Formula: C21H27N3O3S * 2HCl
Molecular weight: 474.44
Source/Host: Synthetic
Purity: >99%
Solubility: Soluble to 100mM in water and to 50mM in DMSO.
Appearance: White solid
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C
Safety Phrases: Classification: Caution: Substance not yet fully tested.

Safety Phrases: S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Hazard Phrases: H302-H315-H317-H318-H335

Precautionary Phrases: P261-P280-P305 + P351 + P338
Datasheet: SIH 317 E 4031 Ion Channel Inhibitor
Price: $465.00 USD Add to Cart Bulk Quote

Structure of E-4031

Research Background: E-4031 acts on a specific class of voltage gated potassium channels, the hERG channels. It does this by binding to the open channels, although its structural target is unclear (1-4). It is also an anti-arrhythmic drug (5).
References: 1. Gerlach A.C., Stoehr S.J., Castle N.A. (2010) Mol Pharmacol. 77(1): 56-68.
2. Perrin M.J., et al. (2008) Prog Biophys Mol Biol. 98: 137-148.
3. Sanguinetti M.C., Jurkiewicz N.K. (1990) J Gen Physiol. 96: 195-215.
4. Spector P.S., Curran M.E., Keating M.T., and Sanguinetti M.C. (1996) Circ Res. 78: 499-503.
5. Miyake K., et al. (1990) J Med Chem. 33: 903.

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